When a failed nuclear fusion experiment results in an explosion that kills his wife, Dr. Otto Octavius (Alfred Molina) is transformed into Dr. Octopus, a cyborg with deadly metal tentacles. Doc Ock blames Spider-Man (Tobey Maguire) for the accident and seeks revenge. Meanwhile, Spidey's alter ego, Peter Parker, faces fading powers and self-doubt. Complicating matters are his best friend's (James Franco) hatred for Spider-Man and his true love's (Kirsten Dunst) sudden engagement to another man.
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